Health and Beauty

Osteoporosis En Espanol

  • What's hot

    Conceptos de salud pública y estrategias preventivas + StudentConsult en español: Un manual para ciencias de la salud (Spanish Edition)
    eBooks (Elsevier)


    Densitometría Ósea como Predictivo de Fracturas de Cadera en Gerontes: Osteoporosis, Promoción y Prevención de Salud (Spanish Edition)
    Book (Editorial Académica Española)

    Editorial Académica Española

    List Price: $59.00

A closer look at osteoporosis medication's mechanisms may ...

Osteoporosis is the primary cause of bone fractures in the elderly. Bone loss in this disease reflects an imbalance between the activity of bone-degrading cells called osteoclasts and bone-building cells called osteoblasts. Teriparatide, a recombinant form of parathyroid hormone, is currently the only FDA-approved treatment for osteoporosis that targets bone formation. This medication stimulates osteoblast activity and increases the lifespan of osteoblasts, but whether it also enhances the production of these bone-forming cells is unknown.

New findings from Henry Kronenberg's lab at Massachusetts General Hospital and Harvard Medical School suggest that while teriperatide treatment does increase the proliferation of osteoblasts, stopping treatment may have adverse effects. A study published this week in the JCI reports that the number of osteoblast precursor cells and their mature descendants increased in mice undergoing teriparatide treatment. When mice were withdrawn from teriparatide treatment, not only did osteoblast proliferation diminish, but the number of newly-formed fat cells, or adipocytes, increased.